Professor Ma Wei-Ying, Professor Nie Zaiqing, and Associate Professor Zhou Hao, along with research teams from Peking University, Nanjing University, and Shuimu Molecules, have developed the ESM-AA model. This model represents a significant advancement in the field of protein language modeling, offering a unified modeling framework that integrates information across multiple scales. ESM-AA is the first protein pre-training language model capable of simultaneously processing amino acid and atomic information.
The model's outstanding performance illustrates the immense potential of multi-scale unified modeling in overcoming existing limitations and unlocking new capabilities. As a foundational model, ESM-AA has garnered attention and extensive discussion among scholars, with the potential to develop models that can compete with AlphaFold3 and RoseTTAFold All-Atom, paving new avenues for studying interactions between different biological structures. The related paper has been accepted for presentation at ICML 2024.
Paper Link:
https://arxiv.org/abs/2403.12995
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